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Cognitive Performance Improved By Weight-Loss Surgery: 2018 JAMA Study

Posted on: 6th Dec, 2019

Obesity adversely affects brain function, but the effect of bariatric surgery on cognitive function had not been rigorously evaluated. A recent JAMA study assessed metabolic parameters and cognitive function in obese patients before and after bariatric surgery. And the results are striking: significant improvement in cognitive function as measured by both the Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) 6 months after bariatric surgery (p<0.03). Neuronal plasticity (NP) also improved significantly as measured by neuronal plasticity (NP) of the visual cortex – measured as change in ocular dominance after 120 min monocular deprivation.
 
In a similar prior study, Alosco and colleagues published data showing improved cognitive function across several domains including memory, executive function, attention, and language.
 
 
Cognitive performance is negatively influenced in obesity by multiple factors including “brain aging”, fatigue, depression, sleep deprivation, pain, lowered attention, cerebrovascular disease, and medications.
 
Exercise has been shown to improve brain function by promoting neurogenesis and slowing apoptosis, among other mechanisms. So it comes as no surprise that treating obesity with metabolic surgery might result in improved cognitive performance as well as the many other associated obesity-related conditions.
 
In Dardano’s paper in Diabetes, 10 obese subjects were administered a battery of evaluations to assess neuronal plasticity and cognitive function. Six months after surgery, a large amount of weight had been lost, and MoCA, MMSE and NP all significantly improved, indicating a measurable impact of improved cognitive performance and neuroplasticity after metabolic surgery.
 
In a demonstration of Level 1A evidence, 12 published randomized controlled trials demonstrate that metabolic surgery is superior to intensive medical management of type 2 diabetes.
 
After surgery, most individuals with Type 2 diabetes enjoy a significant period of remission, defined by euglycemia without medications. The American Diabetes Association now recommends metabolic surgery for all patients with Type 2 diabetes and a BMI over 35. The American Heart Association now recommends consideration of metabolic surgery for patients with hypertension and BMI of 35 or greater.
 
And now, list cognitive function among the expected benefits from metabolic surgery among obese individuals.
 
These long-term benefits come without the side effects of a bypass surgical procedure. In over 1,700 consecutive laparoscopic sleeve gastrectomy procedures, Dr. Sasse has had 0.0% rate of leak, the most troublesome complication of metabolic surgery.
 
 
* Dardano, A., Daniele, G., Lunghi, C., Ciccarone, A., Santini, F., Ceccarini, G., Moretto, C., Penno, G., Miccoli, R., Morrone, M.C. and Del Prato, S., 2018. Cognitive Function and Brain Plasticity in Obese Patients—The Impact of Bariatric Surgery.
* Alosco, M.L., Spitznagel, M.B., Strain, G., Devlin, M., Cohen, R., Paul, R., Crosby, R.D., Mitchell, J.E. and Gunstad, J., 2014. Improved memory function two years after bariatric surgery. Obesity, 22(1), pp.32-38.
* Fisher, D.P., Johnson, E., Haneuse, S., Arterburn, D., Coleman, K.J., O’Connor, P.J., O’Brien, R., Bogart, A., Theis, M.K., Anau, J. and Schroeder, E.B., 2018. Association between bariatric surgery and macrovascular disease outcomes in patients with type 2 diabetes and severe obesity. JAMA, 320(15), pp.1570-1582.
 
 

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