Are there long-term risks of GLP-1 medications?

Posted on: 2nd Jun, 2025

TL;DR:

GLP-1 drugs like Ozempic, Wegovy, and Mounjaro may pose long-term concerns including digestion problems, muscle loss, mood changes, gallstones, and cancer risk.
GLP-1 drugs can cause gastroparesis, leading to swelling, pain, and nausea, while Bariatric surgery avoids long-term stomach issues.
Rapid weight loss caused by GLP-1 drugs may result in muscle loss, however, bariatric surgery offers better muscle mass preservation.
GLP-1 drugs carry a risk of pancreatitis and potentially pancreatic cancer, whereas bariatric surgery decreases cancer risks.
GLP-1 drugs have a black box warning for thyroid tumors, but this risk does not exist with bariatric surgery. However, both treatments carry gallstone risks.
While GLP-1 aids short-term, bariatric surgery offers sustainable and effective long-term health and weight management solutions.
There are many uncertainties about the long-term impacts of GLP-1 drugs, making bariatric surgery a more reliable method.

GLP-1 medications like Ozempic and Wegovy can aid weight loss, but what about their risks? At the Incontinence Center at Nevada Surgical, we prioritize your long-term health and wellness. I’m Dr. Kent Sasse, here to explore the potential long-term side effects of GLP-1 medications. Are these treatments safe for everyone, and what should you consider before starting? Let’s dive into the facts and ensure you make informed health choices.

Long-Term Side Effects of GLP-1 Receptor Agonists

GLP-1 drugs like Ozempic, Wegovy, and Mounjaro are used to control blood sugar and aid in weight loss. However, long-term use raises important concerns. Below we discuss potential side effects and why bariatric surgery might be a better solution.

Common Side Effects

Short-Term: Nausea, feeling full, bloating, and diarrhea are usual in the beginning. For some, nausea doesn’t go away.

Long-Term: The effects build up slowly and can turn serious. Issues include digestion problems, muscle loss, mood changes, gallstones, and cancer risk.

Digestion Concerns

GLP-1 drugs can cause “gastroparesis,” a condition where the stomach empties slowly. This can lead to swelling, pain, and nausea.

Bariatric surgery also slows stomach emptying but reshapes the stomach, avoiding long-term issues like chronic bloating. Surgery tends to offer better results with fewer stomach problems over time.

Muscle Loss

Rapid weight loss with GLP-1 drugs can cause muscle loss, as much as 40% of total weight loss. Muscle is essential for mobility, joint support, and energy.

Bariatric surgery patients receive guidance on protein intake and exercise, preserving muscle mass better than with GLP-1 drugs.

Pancreas and Cancer Risks

GLP-1 drugs carry concerns about pancreatitis and potential links to pancreatic cancer. These links are not fully understood but remain a worry due to limited long-term study data.

Bariatric surgery is associated with decreased cancer risks, including breast, colon, and pancreatic cancer. It offers a more reliable long-term safety profile compared to GLP-1 drugs.

Thyroid Tumors and Gallbladder Issues

There is a black box warning for thyroid tumors with GLP-1 drugs. Bariatric surgery does not have this risk. Gallstones and gallbladder disease are concerns with both GLP-1s and weight loss surgery, but surgery includes preventive steps, like medications to protect the gallbladder.

Mood Changes

Some patients on GLP-1s report feeling sad or having mood changes. Surgery patients go through mood changes too, but they get support from care teams, which has shown to improve mood over time.

Surgery vs. GLP-1 for Long-Term Results

While GLP-1 drugs can help in the short term, they often lead to a cycle of weight regain and continued health monitoring. Bariatric surgery tends to produce lasting weight loss and health improvements by altering the body’s hormones permanently.

What’s Safe Long-Term?

GLP-1 drugs are approved for over a year in clinical trials, but many uncertainties remain about long-term impacts. Weight regain, muscle loss, and gallbladder issues pose significant concerns.

Choosing bariatric surgery often offers a safer, more effective long-term solution for sustainable weight and health management, with ongoing support and fewer unknowns.

In conclusion, while GLP-1 drugs offer short-term help, their long-term use raises many questions and potential risks. Bariatric surgery provides a more reliable, long-term path to health and weight stability with well-documented benefits.

##Conclusion

We’ve explored the long-term risks of GLP-1 medications. These drugs, like semaglutide and liraglutide, can help with weight loss but may have side effects. Possible issues include nausea, muscle loss, and cancer risks. It’s important to consider treatment duration, especially as endocrinologists suggest caution. Regular check-ups help in monitoring side effects. Always weigh the benefits against the risks, and consult with healthcare experts to decide if these drugs are right for your needs. Your health and safety should always come first.

Ready to take control of your health for the long term? Discover the benefits of bariatric surgery and make an informed choice for sustainable weight management and improved health. [Contact Nevada Surgical](https://forms.aweber.com/form/55/310012255.htm) today to learn more about how bariatric surgery can be a safer, more effective solution for you. Your journey to lasting health starts here!

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